Monday, June 8, 2009
Healthy Eating
Checkout this youtube video for quick tips http://www.youtube.com/watch?v=0i4DK0tRYps
Sunday, June 7, 2009
Triple Negative News
Elena got this article from a friend...Not sure of the source....
Progress against cancer does not move at a constant velocity; sometimes there are watershed moments when the pace accelerates…..”
Yesterday, at the annual meeting of the American Society of Clinical Oncology was one of those moments; another milestone in the treatment of breast cancer.
We saw one of those major milestones in this decade when Herceptin was introduced for the treatment of HER2+ metastatic breast cancer. A whole new modality of treatment, targeted biological therapy, then became established as an important component of adjuvant treatment in earlier stage breast cancer.
Now, "the biggest story in breast cancer right now is the PARP inhibitors," Clifford Hudis, chief of breast cancer medicine at Memorial Sloan Kettering Cancer Center was quoted during a recent interview. "Any time you open up a new target, that's an exciting moment. These drugs may potentially be active not just to treat metastatic disease but to prevent recurrence."
And excitement there was, as news of PARP inhibitors was presented at the annual meeting attended by more than 30,000 oncologists. Even more exciting was that PARP inhibitors are being shown to be effective in triple negative tumors which often affects younger women at a higher rate and is responsible for about 15 percent of all breast cancer.
Since triple negative breast cancer lacks the three genetic targets needed for hormonal and Her2 therapies, the only effective treatment had been chemotherapy. It’s about time we have an effective targeted therapy for this form of the disease which occurs in about 15 percent of all breast cancers and affects younger women more than other forms.
“If the cancer is detected early enough, treatment with a PARP inhibitor may be able to permanently destroy the tumors…” , Barry Sherman, chief medical officer of Bi-Par Sciences, Inc. said in an interview at the conference yesterday. “There is an opportunity here to actually use the term 'cure' when it's applied to early-stage disease. That is perhaps one of the most exciting notions to come out of this. This is the forefront of a field that is about to open up, about DNA repair."
Bi-Par Sciences, recently purchased by Sanofi-Aventis, presented Phase II trial results that showed that their experimental cancer drug helped patients with advanced breast tumors live more than 60 percent longer using this new method that stops diseased cells from healing themselves.
The treatment, called BSI-201, shrank tumors and slowed new growth in a study of 116 patients with triple- negative breast cancer.
BSI-201 leads this exciting and emerging class of treatments known as PARP inhibitors. Most cancer treatments work by blasting DNA with chemotherapy or radiation. Cancer can fight back by using PARP enzymes to fix damaged strands of DNA. The new medicines are designed to block the enzymes and kill the cancer.
There are six different repair mechanisms in healthy human cells to repair DNA. When cancer develops, many of those mechanisms break down and leave the cell dependent on PARP to fix genetic damage from cancer treatments. Researchers have found that several forms of cancer in the ovaries, uterus, lungs and pancreas all have unusually high PARP enzyme activity, making them good targets for new therapies in other cancers as well, opening up a new era of cancer treatment.
In Sanofi's study, half of patients were given BSI-201 and a combination of chemotherapies, carboplatin and Eli Lilly & Co.'s Gemzar, and half were given chemo and a placebo. About 60 percent of patients who took BSI-201 saw their tumors shrink and cancer slow, almost three times as many as those who took only chemotherapy.
The median lifespan after treatment with BSI-201 was 9.2 months, compared with 5.7 months in the control group. Sometimes a few months might seem like baby steps, but these numbers are significant even in relation to our earlier blockbuster treatment, Herceptin. In highly pre-treated metastatic women, these additional months are noteworthy, and we are hopeful to see even more significant numbers in earlier stage women.
There were no significant side effects from the BSI-201 treatment, which was added to standard chemotherapy in this research trial. A separate study was presented at the conference showing that a similar PARP inhibitor, called olaparib and made by AstraZeneca Plc, shrank tumors even when administered without chemotherapy or radiotherapy.
Sanofi will begin enrollment for an expanded trial of 400 patients in the next two months to confirm the results and the company estimates this could take as little as a year to complete before submitting to FDA regulators for market approval.
PARP inhibitors are the biggest story in breast cancer right now and another milestone on our war against the disease!
There is more hope!!!
Progress against cancer does not move at a constant velocity; sometimes there are watershed moments when the pace accelerates…..”
Yesterday, at the annual meeting of the American Society of Clinical Oncology was one of those moments; another milestone in the treatment of breast cancer.
We saw one of those major milestones in this decade when Herceptin was introduced for the treatment of HER2+ metastatic breast cancer. A whole new modality of treatment, targeted biological therapy, then became established as an important component of adjuvant treatment in earlier stage breast cancer.
Now, "the biggest story in breast cancer right now is the PARP inhibitors," Clifford Hudis, chief of breast cancer medicine at Memorial Sloan Kettering Cancer Center was quoted during a recent interview. "Any time you open up a new target, that's an exciting moment. These drugs may potentially be active not just to treat metastatic disease but to prevent recurrence."
And excitement there was, as news of PARP inhibitors was presented at the annual meeting attended by more than 30,000 oncologists. Even more exciting was that PARP inhibitors are being shown to be effective in triple negative tumors which often affects younger women at a higher rate and is responsible for about 15 percent of all breast cancer.
Since triple negative breast cancer lacks the three genetic targets needed for hormonal and Her2 therapies, the only effective treatment had been chemotherapy. It’s about time we have an effective targeted therapy for this form of the disease which occurs in about 15 percent of all breast cancers and affects younger women more than other forms.
“If the cancer is detected early enough, treatment with a PARP inhibitor may be able to permanently destroy the tumors…” , Barry Sherman, chief medical officer of Bi-Par Sciences, Inc. said in an interview at the conference yesterday. “There is an opportunity here to actually use the term 'cure' when it's applied to early-stage disease. That is perhaps one of the most exciting notions to come out of this. This is the forefront of a field that is about to open up, about DNA repair."
Bi-Par Sciences, recently purchased by Sanofi-Aventis, presented Phase II trial results that showed that their experimental cancer drug helped patients with advanced breast tumors live more than 60 percent longer using this new method that stops diseased cells from healing themselves.
The treatment, called BSI-201, shrank tumors and slowed new growth in a study of 116 patients with triple- negative breast cancer.
BSI-201 leads this exciting and emerging class of treatments known as PARP inhibitors. Most cancer treatments work by blasting DNA with chemotherapy or radiation. Cancer can fight back by using PARP enzymes to fix damaged strands of DNA. The new medicines are designed to block the enzymes and kill the cancer.
There are six different repair mechanisms in healthy human cells to repair DNA. When cancer develops, many of those mechanisms break down and leave the cell dependent on PARP to fix genetic damage from cancer treatments. Researchers have found that several forms of cancer in the ovaries, uterus, lungs and pancreas all have unusually high PARP enzyme activity, making them good targets for new therapies in other cancers as well, opening up a new era of cancer treatment.
In Sanofi's study, half of patients were given BSI-201 and a combination of chemotherapies, carboplatin and Eli Lilly & Co.'s Gemzar, and half were given chemo and a placebo. About 60 percent of patients who took BSI-201 saw their tumors shrink and cancer slow, almost three times as many as those who took only chemotherapy.
The median lifespan after treatment with BSI-201 was 9.2 months, compared with 5.7 months in the control group. Sometimes a few months might seem like baby steps, but these numbers are significant even in relation to our earlier blockbuster treatment, Herceptin. In highly pre-treated metastatic women, these additional months are noteworthy, and we are hopeful to see even more significant numbers in earlier stage women.
There were no significant side effects from the BSI-201 treatment, which was added to standard chemotherapy in this research trial. A separate study was presented at the conference showing that a similar PARP inhibitor, called olaparib and made by AstraZeneca Plc, shrank tumors even when administered without chemotherapy or radiotherapy.
Sanofi will begin enrollment for an expanded trial of 400 patients in the next two months to confirm the results and the company estimates this could take as little as a year to complete before submitting to FDA regulators for market approval.
PARP inhibitors are the biggest story in breast cancer right now and another milestone on our war against the disease!
There is more hope!!!
Saturday, June 6, 2009
Breakfast Club Meeting One
We started a group. I hate to say support group because I don't like most support groups. Too depressing and unrelated to me, but we are doing something a little hipper! It's at my house (or whoever would like to host), there is good healthy (and unhealthy) food, some flowers on the table and great discussion. I felt really glad I did this. We started at 10am and before you knew it it was 1:30! We obviously needed to talk and really clicked with one another.
This month Amy who is in chemo currently and going to be doing a mastectomy and rebuild showed up having never met any of us! I was put in contact with her through our mutual plastic surgeon. She is still making the BRCA positive decision of whether to have ovaries and uterus out or just ovaries. Thank you for coming with your gentle nature, bandanna and chemo fog!
Tami is also mid chemo and in wig looking fabulous! She is waiting to hear here genetic testing results and struggling with the order of reconstruction. Should you do radiation then reconstruction or reconstruction then radiation???? We love her tenacity and search for answers. I know she will struggle and struggle and then do what her heart tells her is right for her. We shared our stories of reconstruction and will send our good energy or prayers her way.
Margaret an original Breakfast Club girl came with her great positive relaxed energy! She told her story of being diagnosed and treated for colon cancer then having surgery with complications that landed her in the hospital for 9 weeks only to find out it was probably ovarian cancer and then being treated for ovarian cancer. She is a living miracle right now currently beating an aggressive cancer and in remission.
Elizabeth came with her free spirit feeling more and more confident and further and further away from the cancer that once enveloped every thought. Her hair is back with a vengeance and growing strong. She talked to us about eating to boost your immune system and we decided we could talk about it at several meetings to come as it is a large topic.
Elena came with her bubbly spirit and advocated for second opinions and lots of questions. she shared her story of reconstruction with radiation and the faith that her radiated skin will hold out in expansion for her and if not she will move from there. She also had a lot of information on healthy eating.
Mary was there in spirit and we missed her, but she had to work and we're glad because she is a single mom and needs her Saturday hours!! See you next time dear.
I was there as the picture of what not to do in the eating area. We established that I eat red meat, monkey bread, dairy and drink alcohol and am going to continue to do so, but I also found a way to have sex after menopause using Premarin cream so I trump all the good food in the world! I may die young but I'll be full and sexed!!!!! I do also advocate weight training and low body fat!
Some interesting information to share:
**There is currently work on an after chemo drug for triple negative girls. Tami I think you said you had a website about it so please hit comment below and fill us in.
**Elena told us about Zometa. It was given to older patients to prevent bone loss and it was consequently discovered it reduced recurrence of breast cancer as well. She is getting it as an infusion. It was thought that there may also be a pill form. Oncologists are starting to give it on a regular basis to younger patients now. Elena please hit comment and give us all the facts you have on it please.
**Amy told us about a new radiation machine that more directly targets tumors while sparing healthy tissue. She mentioned a cream to put on radiated skin called Biofine. We think that's how it is spelled and it is recommended.
**Elena recommended the book Crazy Sexy Cancer. She also has lots of info on nutrition. She recommends minimizing dairy, sugar and fat from your diet and staying as plant based as you can. She takes several classes at the Wellness Center and it is a great resource. Here is their website. Their calendar of classes can be found there.
**Elizabeth agrees that a plant based diet is best and moderation on dairy, sugar and fat as well. She is also an advocate for organic eating as much as possible. She introduced us to Bora Bora Bars, organic green tea at Trader Joe's, and gave us a list of Cruciferous vegetables. That list is available at Wikipedia. http://en.wikipedia.org/wiki/Cruciferous_vegetables. Cruciferous vegetables contain many anti cancer properties.
She also presented an article from the New York Times that warns of the hazards of grilled meats. Grilling creates HCA's that have triggered breast, colon and prostate tumors in rats. There are tips in the article for making grilled meat safer.
1. Precook in the microwave to reduce time on the grill.
2. Go heavy on the marinades they blunt the heat and reduce the number of HCA's formed.
3. Add broccoli or any other cruciferous vegie. They help metabolize the toxins in grilled meat more efficiently.
4 Avoid well done meat. Aim for medium or rare!
**Margaret is participating in Relay for Life on August 8-9. You can go to www.RelayForLife.org/martinezca her team is Angels for Margaret.
Sign up as a survivor and get a free shirt and you can join her team and walk a few laps as well. The time commitment is however many laps you want to choose. We discussed signing up and walking together for fun. You can also donate there if you are interested. There is no pressure to do this, but it could be fun! Relay For Life benefits all cancer research not just breast.
**I filled the girls in on the joys of menopause. I gave information on sexual side effects of dryness and the ways it can be handled. If you are not estrogen positive you can talk to your doctor about Premarin cream. If you are estrogen positive talk to them about testosterone cream. Small amounts of hormone do leach into the blood stream, but my oncologist and gynecologist felt it was negligible. You apply the cream daily for 2 weeks and then twice a week for maintenance. Elizabeth discovered something called the Estring which I hope she comments on below! It is inserted every 3 months and does a slow release of estrogen.
Please comment where I fell short in my note taking. We may need a minutes person next time and I have a sneaking suspicion that Tami or Elena would be good at that.
We'll meet again in a month.
Peace
tammie
This month Amy who is in chemo currently and going to be doing a mastectomy and rebuild showed up having never met any of us! I was put in contact with her through our mutual plastic surgeon. She is still making the BRCA positive decision of whether to have ovaries and uterus out or just ovaries. Thank you for coming with your gentle nature, bandanna and chemo fog!
Tami is also mid chemo and in wig looking fabulous! She is waiting to hear here genetic testing results and struggling with the order of reconstruction. Should you do radiation then reconstruction or reconstruction then radiation???? We love her tenacity and search for answers. I know she will struggle and struggle and then do what her heart tells her is right for her. We shared our stories of reconstruction and will send our good energy or prayers her way.
Margaret an original Breakfast Club girl came with her great positive relaxed energy! She told her story of being diagnosed and treated for colon cancer then having surgery with complications that landed her in the hospital for 9 weeks only to find out it was probably ovarian cancer and then being treated for ovarian cancer. She is a living miracle right now currently beating an aggressive cancer and in remission.
Elizabeth came with her free spirit feeling more and more confident and further and further away from the cancer that once enveloped every thought. Her hair is back with a vengeance and growing strong. She talked to us about eating to boost your immune system and we decided we could talk about it at several meetings to come as it is a large topic.
Elena came with her bubbly spirit and advocated for second opinions and lots of questions. she shared her story of reconstruction with radiation and the faith that her radiated skin will hold out in expansion for her and if not she will move from there. She also had a lot of information on healthy eating.
Mary was there in spirit and we missed her, but she had to work and we're glad because she is a single mom and needs her Saturday hours!! See you next time dear.
I was there as the picture of what not to do in the eating area. We established that I eat red meat, monkey bread, dairy and drink alcohol and am going to continue to do so, but I also found a way to have sex after menopause using Premarin cream so I trump all the good food in the world! I may die young but I'll be full and sexed!!!!! I do also advocate weight training and low body fat!
Some interesting information to share:
**There is currently work on an after chemo drug for triple negative girls. Tami I think you said you had a website about it so please hit comment below and fill us in.
**Elena told us about Zometa. It was given to older patients to prevent bone loss and it was consequently discovered it reduced recurrence of breast cancer as well. She is getting it as an infusion. It was thought that there may also be a pill form. Oncologists are starting to give it on a regular basis to younger patients now. Elena please hit comment and give us all the facts you have on it please.
**Amy told us about a new radiation machine that more directly targets tumors while sparing healthy tissue. She mentioned a cream to put on radiated skin called Biofine. We think that's how it is spelled and it is recommended.
**Elena recommended the book Crazy Sexy Cancer. She also has lots of info on nutrition. She recommends minimizing dairy, sugar and fat from your diet and staying as plant based as you can. She takes several classes at the Wellness Center and it is a great resource. Here is their website. Their calendar of classes can be found there.
**Elizabeth agrees that a plant based diet is best and moderation on dairy, sugar and fat as well. She is also an advocate for organic eating as much as possible. She introduced us to Bora Bora Bars, organic green tea at Trader Joe's, and gave us a list of Cruciferous vegetables. That list is available at Wikipedia. http://en.wikipedia.org/wiki/Cruciferous_vegetables. Cruciferous vegetables contain many anti cancer properties.
She also presented an article from the New York Times that warns of the hazards of grilled meats. Grilling creates HCA's that have triggered breast, colon and prostate tumors in rats. There are tips in the article for making grilled meat safer.
1. Precook in the microwave to reduce time on the grill.
2. Go heavy on the marinades they blunt the heat and reduce the number of HCA's formed.
3. Add broccoli or any other cruciferous vegie. They help metabolize the toxins in grilled meat more efficiently.
4 Avoid well done meat. Aim for medium or rare!
**Margaret is participating in Relay for Life on August 8-9. You can go to www.RelayForLife.org/martinezca her team is Angels for Margaret.
Sign up as a survivor and get a free shirt and you can join her team and walk a few laps as well. The time commitment is however many laps you want to choose. We discussed signing up and walking together for fun. You can also donate there if you are interested. There is no pressure to do this, but it could be fun! Relay For Life benefits all cancer research not just breast.
**I filled the girls in on the joys of menopause. I gave information on sexual side effects of dryness and the ways it can be handled. If you are not estrogen positive you can talk to your doctor about Premarin cream. If you are estrogen positive talk to them about testosterone cream. Small amounts of hormone do leach into the blood stream, but my oncologist and gynecologist felt it was negligible. You apply the cream daily for 2 weeks and then twice a week for maintenance. Elizabeth discovered something called the Estring which I hope she comments on below! It is inserted every 3 months and does a slow release of estrogen.
Please comment where I fell short in my note taking. We may need a minutes person next time and I have a sneaking suspicion that Tami or Elena would be good at that.
We'll meet again in a month.
Peace
tammie
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